Linked Life Data

3664452

Source:http://linkedlifedata.com/resource/pubmed/id/3664452

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1987-11-23
pubmed:abstractText
The metabolism of 7-ethyl (7-EBA) and 7-methylbenz[a]anthracene (7-MBA) to dihydrodiols has been compared in incubations with hepatic microsomal fractions prepared from untreated rats. Although both hydrocarbons were found to be metabolised to similar extents, the relative proportions of their diols that were detected differed. For 7-MBA, the principal diols identified were the 8,9- and 5,6-derivatives, whereas for 7-EBA the 8,9- and 1,2-diols predominated; the 5,6-diol was only present as a minor product. These results imply that the presence of the sterically bulky ethyl group at position seven in the benz[a]anthracene ring system may, when compared to the analogous methyl derivative, enhance diol formation on the angular 1,2,3,4 benzo-ring, at the expense of metabolism at the K-region.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0304-3835
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
71-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Comparative metabolism of 7-methyl- and 7-ethylbenz[a]anthracene by rat-liver preparations.
pubmed:affiliation
Chester Beatty Laboratories, Institute of Cancer Research: Royal Cancer Hospital, London, U.K.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't