Linked Life Data

3659570

Source:http://linkedlifedata.com/resource/pubmed/id/3659570

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1987-11-18
pubmed:abstractText
Administration of bromotrichloromethane (BrCCl3) to rats results in selective damage to bronchiolar non-ciliated Clara cells; ciliated bronchiolar cells and pneumocytes were unaffected. The cellular alterations begin very early (10 min) after poisoning. Lipid peroxidation, as measured by the malonic dialdehyde (MDA) content in the lung, is greatly increased 10 min after BrCCl3 administration. A histochemical technique to detect, in vitro, lipid peroxidation in frozen sections was used to demonstrate whether sufficient activation of BrCCl3 occurs in lung tissue. The positivity for the histochemical reaction was observed in bronchiolar epithelium in which cytochrome P450-dependent monooxygenase activity is predominantly located. The data obtained strongly support that BrCCl3 is highly metabolized in bronchiolar Clara cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0034-5164
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
213-28
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Bromotrichloromethane-induced damage to bronchiolar Clara cells.
pubmed:affiliation
Institute of General Pathology, University of Siena, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't