Linked Life Data

3659117

Source:http://linkedlifedata.com/resource/pubmed/id/3659117

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1987-11-10
pubmed:abstractText
In male Wistar rats, ascorbic acid (AA) (1 gr/kg i.p.) significantly (P less than 0.05) decreased the rate of CAR in the shuttle box avoidance test and antagonized the d-amphetamine (d-A) (1 mg/kg s.c.)-induced increase of CAR. Shuttle box test reduced striatal dopamine (DA) levels by about 86% (with a consistent 2-3 fold increase of DOPAC levels). DA levels were greatly reduced also in hypothalamus (HYP) and in hippocampus (HIP). AA further decreased striatal DA but significantly antagonized the reduction of DA levels in HYP and HIP. d-A antagonized the reduction of DA levels in all the above brain regions. Shuttle box test reduced noradrenaline (NA) levels mainly in HIP (-52%) and again d-A showed a significant protective effect in all regions; AA did not interfere with NA level reduction in striatum (ST) and HYP, but antagonized it in HIP. It is concluded that striatal DA system plays an important role in rat operant active avoidance behaviour. AA seems to exert a negative modulatory activity which can be counteracted by d-A.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0031-6989
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
441-50
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Neurochemical and behavioural changes induced by ascorbic acid and d-amphetamine in the rat.
pubmed:affiliation
Institute of Pharmacology, University of Sassari, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't