Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
|
pubmed:dateCreated |
1987-11-6
|
pubmed:abstractText |
Twenty-four patients with recurrent or widespread adenocarcinoma of the cervix were treated with combination chemotherapy. The drugs used were 5-fluorouracil (5-FU) (500 to 800 mg/m2), doxorubicin (40 to 50 mg/m2), and cisplatin (50 to 60 mg/m2). The chemotherapy was administered as a 76-hour continuous infusion via a silastic central venous catheter and repeated every 28 days. The total response rate was 42% (25% complete and 17% partial). Median duration of response was 7 months. Areas of response were usually lung and lymph node metastases. Toxicity, mainly neutropenia, was acceptable. All patients relapsed. This combination chemotherapy results in a modest response rate for a malignancy about which there is little information regarding the treatment of disseminated disease. Future studies should determine the activity of this combination administered in a bolus fashion.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0732-183X
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
5
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1621-3
|
pubmed:dateRevised |
2006-4-24
|
pubmed:meshHeading |
pubmed-meshheading:3655859-Adenocarcinoma,
pubmed-meshheading:3655859-Adult,
pubmed-meshheading:3655859-Ambulatory Care,
pubmed-meshheading:3655859-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:3655859-Cisplatin,
pubmed-meshheading:3655859-Doxorubicin,
pubmed-meshheading:3655859-Drug Evaluation,
pubmed-meshheading:3655859-Female,
pubmed-meshheading:3655859-Fluorouracil,
pubmed-meshheading:3655859-Hospitalization,
pubmed-meshheading:3655859-Humans,
pubmed-meshheading:3655859-Middle Aged,
pubmed-meshheading:3655859-Neoplasm Recurrence, Local,
pubmed-meshheading:3655859-Uterine Cervical Neoplasms
|
pubmed:year |
1987
|
pubmed:articleTitle |
Combination chemotherapy for metastatic or recurrent adenocarcinoma of the cervix.
|
pubmed:affiliation |
H. Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa 33612-9497.
|
pubmed:publicationType |
Journal Article
|