| pubmed-article:3654792 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3654792 | lifeskim:mentions | umls-concept:C0328631 | lld:lifeskim |
| pubmed-article:3654792 | lifeskim:mentions | umls-concept:C0026046 | lld:lifeskim |
| pubmed-article:3654792 | lifeskim:mentions | umls-concept:C0014921 | lld:lifeskim |
| pubmed-article:3654792 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:3654792 | lifeskim:mentions | umls-concept:C0332197 | lld:lifeskim |
| pubmed-article:3654792 | lifeskim:mentions | umls-concept:C1816458 | lld:lifeskim |
| pubmed-article:3654792 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:3654792 | lifeskim:mentions | umls-concept:C1709305 | lld:lifeskim |
| pubmed-article:3654792 | pubmed:dateCreated | 1987-11-20 | lld:pubmed |
| pubmed-article:3654792 | pubmed:abstractText | We have re-examined the involvement of microtubules in the process of pigment granule transport in squirrelfish erythrophores in situ (i.e. on scales). Light-microscopic studies revealed that following exposure to 5 microM-nocodazole for 1 h at 4 degrees C erythrophores retained an ability to aggregate and disperse their pigment uniformly, though at reduced rates. Serial thick-section stereo high-voltage electron-microscopic studies showed that the entire microtubule population was removed by drug treatment and that the microtubules were not reassembled as a result of pigment translocation processes in the presence of reduced levels of nocodazole (0.4 microM). Immunofluorescence microscopic studies confirmed that nocodazole (0.5-1 microM) produced rapid disassembly of the microtubules. Whole-mount electron-microscopic studies showed that the pigment granules were suspended in a cross-linking network of 3-10 nm filaments, which appeared to support ordered pigment transport in situ in the absence of microtubules. Drug inhibition studies showed that micromolar levels of estramustine, a novel anti-MAPs (microtubule-associated proteins) drug, reversibly inhibited pigment transport. The results suggest that an estramustine-sensitive cytomatrix component might produce polarized pigment transport in intact erythrophores. | lld:pubmed |
| pubmed-article:3654792 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3654792 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3654792 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3654792 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3654792 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3654792 | pubmed:month | May | lld:pubmed |
| pubmed-article:3654792 | pubmed:issn | 0021-9533 | lld:pubmed |
| pubmed-article:3654792 | pubmed:author | pubmed-author:WangMM | lld:pubmed |
| pubmed-article:3654792 | pubmed:author | pubmed-author:StearnsM EME | lld:pubmed |
| pubmed-article:3654792 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3654792 | pubmed:volume | 87 ( Pt 4) | lld:pubmed |
| pubmed-article:3654792 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3654792 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3654792 | pubmed:pagination | 565-80 | lld:pubmed |
| pubmed-article:3654792 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3654792 | pubmed:meshHeading | pubmed-meshheading:3654792-... | lld:pubmed |
| pubmed-article:3654792 | pubmed:meshHeading | pubmed-meshheading:3654792-... | lld:pubmed |
| pubmed-article:3654792 | pubmed:meshHeading | pubmed-meshheading:3654792-... | lld:pubmed |
| pubmed-article:3654792 | pubmed:meshHeading | pubmed-meshheading:3654792-... | lld:pubmed |
| pubmed-article:3654792 | pubmed:meshHeading | pubmed-meshheading:3654792-... | lld:pubmed |
| pubmed-article:3654792 | pubmed:meshHeading | pubmed-meshheading:3654792-... | lld:pubmed |
| pubmed-article:3654792 | pubmed:meshHeading | pubmed-meshheading:3654792-... | lld:pubmed |
| pubmed-article:3654792 | pubmed:meshHeading | pubmed-meshheading:3654792-... | lld:pubmed |
| pubmed-article:3654792 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3654792 | pubmed:articleTitle | Polarized pigment granule transport occurs in the absence of microtubules in squirrelfish erythrophores: studies of the effects of estramustine. | lld:pubmed |
| pubmed-article:3654792 | pubmed:affiliation | Department of Pharmacology, Fox Chase Cancer Center, Philadelphia, PA 19111. | lld:pubmed |
| pubmed-article:3654792 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3654792 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3654792 | lld:pubmed |
