Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1987-10-28
pubmed:abstractText
We have examined soluble sonic extracts prepared from several strains of Centipeda periodontii for their ability to alter human lymphocyte function. These organisms were isolated from subgingival plaque of patients with periodontal disease. We found that sonicates from several, but not all, strains of C. periodontii caused a dose-dependent inhibition of lymphocyte responsiveness to concanavalin A, phytohemagglutinin, pokeweed mitogen, and formalinized Staphylococcus aureus. Inhibition was associated with a concomitant decrease in cell viability assessed by trypan blue exclusion, 51Cr release, and electron microscopy. The maximal number of dead cells was observed 20 to 24 h after exposure to the sonic extract. Susceptible cells include human lymphocytes (both B and T), monocytes, and erythrocytes, whereas polymorphonuclear cells, murine L-929 fibroblasts, and sheep erythrocytes were not affected. Preliminary characterization of the cytotoxic activity indicates that it is heat labile and trypsin sensitive and has an Mr of 60,000. It has been proposed that impaired host defense may play a pivotal role in the pathogenesis of periodontal diseases. The data presented in this paper suggest that immunosuppression (local or systemic or both) could be initiated by C. periodontii. This immunosuppression may alter the nature and consequences of host-parasite interactions, thereby enhancing the pathogenicity of C. periodontii itself or some other opportunistic organism.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-1095003, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-1095482, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-12257, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-135829, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-13986422, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-16558116, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-2934536, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-2935613, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-2935614, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-2936685, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-3546133, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-3988337, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-4008047, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-4209579, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-4281821, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-4546284, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-4992694, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-5662017, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-6155347, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-6202761, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-6214583, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-6218271, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-6224858, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-6227724, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-6230432, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-6232002, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-6234467, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-6319288, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-6336011, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-6337092, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-6338204, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-6338236, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-6381307, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-6401309, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-6429535, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-6436655, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-6457874, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-6600188, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-6600445, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-6602770, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-6698603, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-6699406, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-6707608, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-6715883, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-6966303, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-6972952, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-7054277, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-7056592, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-7152684, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-7160873, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-7228351, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-7228410, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-7399694, http://linkedlifedata.com/resource/pubmed/commentcorrection/3653981-942051
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
55
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2332-40
pubmed:dateRevised
2010-9-10
pubmed:meshHeading
pubmed:year
1987
More...