Linked Life Data

3652207

Source:http://linkedlifedata.com/resource/pubmed/id/3652207

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1987-11-16
pubmed:databankReference
pubmed:abstractText
The neuron R15 is a peptidergic cell within the abdominal ganglion of Aplysia that participates in two neural circuits governing physiological and behavioral programs. We have cloned and characterized the major gene product expressed in this neuron. The R15 cDNA encodes a polyprotein precursor that is cleaved to yield a set of small neuropeptides. One peptide, R15 alpha 1, may act on different target cells to generate distinct but complementary physiological alterations that contribute to a program of cardiovascular changes in Aplysia. We have found that the RNA encoding the R15 polyprotein is spliced differently in different neurons. Our results suggest that alternative splicing of RNAs encoding polyproteins may provide a mechanism to generate distinct but overlapping sets of peptides that govern distinct but related physiological or behavioral programs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0092-8674
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
127-33
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Alternative splicing in individual Aplysia neurons generates neuropeptide diversity.
pubmed:affiliation
Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't