Linked Life Data

3651620

Source:http://linkedlifedata.com/resource/pubmed/id/3651620

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1987-11-16
pubmed:abstractText
The biosynthesis of collagen and elastin was followed during the development of spontaneous hypertension in rats (SHR) of the Okamoto-Aoki strain. Strain-matched animals of the same age, which did not develop hypertension, served as controls. Both collagen and elastin synthesis (as revealed by specific hydroxyproline activity) was found to exceed control levels in the prehypertensive period, to decrease during the development of hypertension and to increase again in the period of the established hypertensive state. From the two main collagen types present, synthesis of collagen type III exceeded that of type I in the prehypertensive period (at the age of 4 weeks) and this relation was reversed during the period of established hypertension. It is suggested that (a) the vascular connective tissue metabolism in SHR differs from that in strain-matched controls, and (b) the reverse rate of collagen type III to collagen type I synthesis during hypertension development may be considered an adaptive response to the increasing pressure load which may alter the mechanical properties of the vessel wall.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0303-6847
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
313-20
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Collagen and elastin synthesis in the aorta of spontaneously hypertensive rats.
pubmed:affiliation
Institute of Physiology, Czechoslovak Academy of Sciences, Prague.
pubmed:publicationType
Journal Article