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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1986-7-25
|
| pubmed:abstractText |
Timentin (5.2 g tds) and tobramycin (40 mg tds) were administered to 51 patients (22 male, 29 female, age range 17-72, mean age 40.4) with acute leukaemia, chronic myeloid leukaemia in blastic crisis, severe aplastic anaemia and acute agranulocytopenia. All patients had neutropenia (PMN less than 1000/mm3) and fever (greater than 38 degrees C). Febrile episodes consisted of 22 proved septicaemias due to Gram-positive organisms (Staphylococcus aureus, S. epidermidis, enterococcus) in 11 cases and to Gram-negative organisms (Escherichia coli, Pseudomonas aeruginosa, Alkaligenes faecalis, Serratia marcescens, Klebsiella pneumoniae) in 10 cases. One patient had a polymicrobial infection (P. aeruginosa, S. aureus, non-haemolytic streptococcus). Twenty-nine infections were diagnosed only clinically. The mean duration of treatment was 11.1 days (range 4-20 days). Eighty-seven per cent of evaluable febrile episodes improved. Among 11 infections due to Gram-positive cocci, eight (72%) resolved, and in nine (90%) of ten cases due to Gram-negative bacilli success was obtained. The polymicrobial infection also resolved. In only four patients were mild side effects seen, e.g. exanthema, pruritus, phlebitis: renal toxicity was not observed. These data suggest that the combination of Timentin and tobramycin is an effective and safe empirical antibiotic regimen in febrile neutropenic patients.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Clavulanic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Combinations,
http://linkedlifedata.com/resource/pubmed/chemical/Penicillins,
http://linkedlifedata.com/resource/pubmed/chemical/Ticarcillin,
http://linkedlifedata.com/resource/pubmed/chemical/Tobramycin,
http://linkedlifedata.com/resource/pubmed/chemical/ticarcillin-clavulanic acid
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0305-7453
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
17 Suppl C
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
211-7
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:3636336-Adolescent,
pubmed-meshheading:3636336-Adult,
pubmed-meshheading:3636336-Aged,
pubmed-meshheading:3636336-Agranulocytosis,
pubmed-meshheading:3636336-Anemia, Aplastic,
pubmed-meshheading:3636336-Bacteria,
pubmed-meshheading:3636336-Bacterial Infections,
pubmed-meshheading:3636336-Clavulanic Acids,
pubmed-meshheading:3636336-Drug Combinations,
pubmed-meshheading:3636336-Drug Evaluation,
pubmed-meshheading:3636336-Drug Therapy, Combination,
pubmed-meshheading:3636336-Female,
pubmed-meshheading:3636336-Fever,
pubmed-meshheading:3636336-Humans,
pubmed-meshheading:3636336-Leukemia,
pubmed-meshheading:3636336-Male,
pubmed-meshheading:3636336-Middle Aged,
pubmed-meshheading:3636336-Neutropenia,
pubmed-meshheading:3636336-Penicillin Resistance,
pubmed-meshheading:3636336-Penicillins,
pubmed-meshheading:3636336-Ticarcillin,
pubmed-meshheading:3636336-Tobramycin
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
Timentin in combination with tobramycin as empirical therapy in febrile neutropenic patients with haematological malignancies.
|
| pubmed:publicationType |
Journal Article
|