rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
3
|
pubmed:dateCreated |
1986-4-15
|
pubmed:abstractText |
We successfully treated two patients with severe Staphylococcus epidermidis blepharoconjunctivitis by means of a topical vancomycin hydrochloride solution (50 mg/ml) prepared with sterile water. Aqueous vancomycin preparations, however, cause significant ocular irritation probably because of low pH and osmolality values. Solutions prepared with normal saline (5 mg/ml) and phosphate-buffered artificial tears (5 mg/ml and 50 mg/ml) were significantly less irritating and possessed equivalent in vitro antimicrobial activity. Topical vancomycin should be used only when commercially available antibiotics are inadequate.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0002-9394
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
101
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
283-7
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:3633699-Administration, Topical,
pubmed-meshheading:3633699-Aged,
pubmed-meshheading:3633699-Blepharitis,
pubmed-meshheading:3633699-Conjunctivitis,
pubmed-meshheading:3633699-Drug Evaluation,
pubmed-meshheading:3633699-Eyelid Diseases,
pubmed-meshheading:3633699-Humans,
pubmed-meshheading:3633699-Hydrogen-Ion Concentration,
pubmed-meshheading:3633699-Male,
pubmed-meshheading:3633699-Methicillin,
pubmed-meshheading:3633699-Ophthalmic Solutions,
pubmed-meshheading:3633699-Osmolar Concentration,
pubmed-meshheading:3633699-Penicillin Resistance,
pubmed-meshheading:3633699-Staphylococcal Infections,
pubmed-meshheading:3633699-Staphylococcus epidermidis,
pubmed-meshheading:3633699-Vancomycin
|
pubmed:year |
1986
|
pubmed:articleTitle |
Topical vancomycin formulation for methicillin-resistant Staphylococcus epidermidis blepharoconjunctivitis.
|
pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|