Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1987-10-1
pubmed:abstractText
This study demonstrated that in Portugal HDV infection occurs in 17.3% of HBsAg chronic carriers and chronic HDV infection in 8.4%. As in Northern European countries, HDV infection in Portugal is predominantly found in drug-addicts. Our findings also confirm that HDV infection is associated with an active and progressive liver disease. In delta Ag positive CLD serum HBV-DNA was detected in 10 of 19 cases and was present at low levels. In contrast 52 of 84 delta Ag negative were serum HBV-DNA positive and 48.1% of these had high serum HBV-DNA levels. Ninety per cent of delta Ag positive CLD with serum HBV-DNA positive were drug addicts. These findings indicate that in chronic HDV infection synthesis of HBV is reduced and suggest namely that in drug-addicts their disease derived from the cumulative pathogenic effect of both HBV and HDV. In follow-up biopsy a significantly younger mean age and significantly deterioration of carriers with HDV infection was observed, suggesting that HDV infection accelerates the natural history of HBV related liver disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0361-7742
pubmed:author
pubmed:issnType
Print
pubmed:volume
234
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
409-17
pubmed:dateRevised
2006-4-13
pubmed:meshHeading
pubmed-meshheading:3628400-Adolescent, pubmed-meshheading:3628400-Adult, pubmed-meshheading:3628400-Age Factors, pubmed-meshheading:3628400-Aged, pubmed-meshheading:3628400-Antigens, Viral, pubmed-meshheading:3628400-Carrier State, pubmed-meshheading:3628400-Child, pubmed-meshheading:3628400-Female, pubmed-meshheading:3628400-Hepatitis Antibodies, pubmed-meshheading:3628400-Hepatitis B, pubmed-meshheading:3628400-Hepatitis B Antigens, pubmed-meshheading:3628400-Hepatitis D, pubmed-meshheading:3628400-Hepatitis Delta Virus, pubmed-meshheading:3628400-Hepatitis delta Antigens, pubmed-meshheading:3628400-Humans, pubmed-meshheading:3628400-Liver, pubmed-meshheading:3628400-Male, pubmed-meshheading:3628400-Middle Aged, pubmed-meshheading:3628400-Portugal, pubmed-meshheading:3628400-Retrospective Studies, pubmed-meshheading:3628400-Substance-Related Disorders
pubmed:year
1987
pubmed:articleTitle
Clinical and epidemiological significance of hepatitis delta virus (HDV) infection in chronic HBV carriers in Portugal.
pubmed:publicationType
Journal Article