rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1987-10-1
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pubmed:abstractText |
This study demonstrated that in Portugal HDV infection occurs in 17.3% of HBsAg chronic carriers and chronic HDV infection in 8.4%. As in Northern European countries, HDV infection in Portugal is predominantly found in drug-addicts. Our findings also confirm that HDV infection is associated with an active and progressive liver disease. In delta Ag positive CLD serum HBV-DNA was detected in 10 of 19 cases and was present at low levels. In contrast 52 of 84 delta Ag negative were serum HBV-DNA positive and 48.1% of these had high serum HBV-DNA levels. Ninety per cent of delta Ag positive CLD with serum HBV-DNA positive were drug addicts. These findings indicate that in chronic HDV infection synthesis of HBV is reduced and suggest namely that in drug-addicts their disease derived from the cumulative pathogenic effect of both HBV and HDV. In follow-up biopsy a significantly younger mean age and significantly deterioration of carriers with HDV infection was observed, suggesting that HDV infection accelerates the natural history of HBV related liver disease.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:issn |
0361-7742
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
234
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
409-17
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pubmed:dateRevised |
2006-4-13
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pubmed:meshHeading |
pubmed-meshheading:3628400-Adolescent,
pubmed-meshheading:3628400-Adult,
pubmed-meshheading:3628400-Age Factors,
pubmed-meshheading:3628400-Aged,
pubmed-meshheading:3628400-Antigens, Viral,
pubmed-meshheading:3628400-Carrier State,
pubmed-meshheading:3628400-Child,
pubmed-meshheading:3628400-Female,
pubmed-meshheading:3628400-Hepatitis Antibodies,
pubmed-meshheading:3628400-Hepatitis B,
pubmed-meshheading:3628400-Hepatitis B Antigens,
pubmed-meshheading:3628400-Hepatitis D,
pubmed-meshheading:3628400-Hepatitis Delta Virus,
pubmed-meshheading:3628400-Hepatitis delta Antigens,
pubmed-meshheading:3628400-Humans,
pubmed-meshheading:3628400-Liver,
pubmed-meshheading:3628400-Male,
pubmed-meshheading:3628400-Middle Aged,
pubmed-meshheading:3628400-Portugal,
pubmed-meshheading:3628400-Retrospective Studies,
pubmed-meshheading:3628400-Substance-Related Disorders
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pubmed:year |
1987
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pubmed:articleTitle |
Clinical and epidemiological significance of hepatitis delta virus (HDV) infection in chronic HBV carriers in Portugal.
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pubmed:publicationType |
Journal Article
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