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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3-4
|
| pubmed:dateCreated |
1987-10-6
|
| pubmed:abstractText |
Adriamycin was found to be both mutagenic and clastogenic to L5178Y/TK(+/-)-3.7.2C mouse lymphoma cells. A dose of only 5 ng/ml (survival = 62% or 67%) gave an induced TK mutant frequency of 307 or 296 per 10(6) survivors in two separate experiments. This dose was also clastogenic, inducing 20 chromosome aberrations/100 cells analyzed. The majority of the mutants were small-colony mutants, indicating that adriamycin likely acts primarily by a clastogenic mechanism.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0027-5107
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
191
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
183-8
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:3627155-Animals,
pubmed-meshheading:3627155-Cell Line,
pubmed-meshheading:3627155-Cell Survival,
pubmed-meshheading:3627155-Chromosome Aberrations,
pubmed-meshheading:3627155-Doxorubicin,
pubmed-meshheading:3627155-Leukemia L5178,
pubmed-meshheading:3627155-Mice,
pubmed-meshheading:3627155-Mutagens,
pubmed-meshheading:3627155-Thymidine Kinase
|
| pubmed:articleTitle |
Mutagenicity and clastogenicity of adriamycin in L5178Y/TK(+/-)-3.7.2C mouse lymphoma cells.
|
| pubmed:publicationType |
Journal Article
|