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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1987-9-29
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pubmed:abstractText |
The redox level of [14C]coenzyme Q10 solubilized with HCO-60 in the livers of guinea pigs at 24 h after intravenous injection was approximately 1/4 (18.2% vs. 63.4%) of that of [14C]coenzyme Q10 solubilized with ethanol-water (1:5 by vol). Further, the redox level of coenzyme Q10 (Q10) solubilized with HCO-60 or ethanol-water was 20.2 or 82.3%, respectively, after a 30-min incubation in the liver cytosol. Q10 solubilized with HCO-60 was thus reduced only slightly in vivo or in vitro. The critical micelle concentrations of HCO-60 in the absence and presence of Q10 were 0.02 and 0.002% (w/v), respectively. The concentrations of HCO-60 micelles containing Q10 were estimated to be 0.0048% (w/v) in the incubation mixture with cytosol and 0.0041% (w/v) in blood circulation. These results suggest that HCO-60 micelles containing Q10 would remain more stable not only in blood circulation but also in tissues as compared with ethanol-water emulsion. A possible mode of solubilization of Q10 is discussed.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Castor Oil,
http://linkedlifedata.com/resource/pubmed/chemical/Coenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Micelles,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquinone,
http://linkedlifedata.com/resource/pubmed/chemical/coenzyme Q10,
http://linkedlifedata.com/resource/pubmed/chemical/polyethoxylated castor oil
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0386-846X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
124-7
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:3625446-Animals,
pubmed-meshheading:3625446-Antioxidants,
pubmed-meshheading:3625446-Castor Oil,
pubmed-meshheading:3625446-Coenzymes,
pubmed-meshheading:3625446-Guinea Pigs,
pubmed-meshheading:3625446-Liver,
pubmed-meshheading:3625446-Male,
pubmed-meshheading:3625446-Micelles,
pubmed-meshheading:3625446-Oxidation-Reduction,
pubmed-meshheading:3625446-Solubility,
pubmed-meshheading:3625446-Ubiquinone
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pubmed:year |
1987
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pubmed:articleTitle |
A possible mode of solubilization of coenzyme Q10 with HCO-60.
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pubmed:publicationType |
Journal Article
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