Linked Life Data

3622783

Source:http://linkedlifedata.com/resource/pubmed/id/3622783

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1987-9-28
pubmed:abstractText
Fifty-four intracranial neoplasms (29 meningiomas, 16 gliomas, seven acoustic neuromas and two cerebral metastases) and nine specimens of normal brain were evaluated for specific progesterone and oestrogen receptor proteins using a dextran-coated charcoal assay and Scatchard plot analysis. Sixteen meningiomas (55%) were progesterone receptor (PgR) positive (median 52; mean 120; range 10-486 fmol mg-1 cytosol protein), whilst all were oestrogen receptor negative (ER-). Two (28%) of the acoustic neuromas contained small amounts of PgR protein, but all seven were ER-. None of the gliomas, cerebral metastases or specimens of normal brain contained ER or PgR protein. Analysis of PgR status and clinicopathological data suggest that there is no predictive correlation between PgR status and the patients age, sex, reproductive status, tumour histology or tumour behaviour. These results again suggest that in meningiomas PgR proteins are not modulated by oestrogens acting through ER. This finding may explain the failure of antioestrogen therapy to influence the growth of meningiomas. The significance of PgR protein in intracranial meningiomas is discussed with respect to tumour heterogeneity and implications for research with gene probes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0748-7983
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
303-7
pubmed:dateRevised
2007-7-2
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Sex hormone receptors in intracranial tumours and normal brain.
pubmed:publicationType
Journal Article