Linked Life Data

3620929

Source:http://linkedlifedata.com/resource/pubmed/id/3620929

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1987-9-30
pubmed:abstractText
We have recently reported that ethanol and other n-alkanols added to in vitro assays inhibit the activity of the Na+-Ca2+ exchange system in brain synaptic plasma membrane vesicles. The present studies were undertaken to determine whether in vivo chronic ethanol administration leads to alterations in this Na+-Ca2+ antiporter that might be indicative of an adaptive response to alcohol. The Na+-dependent Ca2+ transport activity in the plasma-membrane fractions obtained was measured at various Ca2+ concentrations. Results of these experiments revealed that a 3-week ethanol regimen brought about a significant increase in the Na+-dependent Ca2+ transport activity only in the membrane fraction enriched in synaptic junctional complexes. These membranes showed a near doubling in the maximal transport activity of the antiporter in alcohol-treated compared with the control animals. Changes in the kinetic parameters were reversible as the Na+-Ca2+ exchange activity in these membranes from animals maintained on alcohol for 3 weeks and then withdrawn for 1 week was indistinguishable from that of membranes from control animals. Thus it appears that ethanol-treated animals make a reversible adaptation in their neuronal cell membranes to compensate for the acute effects of ethanol on the Na+-Ca2+ antiporter.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
414
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
239-44
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Effects of chronic alcohol administration on synaptic membrane Na+-Ca2+ exchange activity.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.