|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:dateCreated |
1987-9-28
|
|
pubmed:abstractText |
1 The pharmacokinetics of isoxicam have been compared in 57 volunteers with an average age of 31.3 years and 48 elderly subjects with an average age of 71.9 years. 2 Isoxicam was given in a single daily dose of 200 mg for up to 22 days. Similar plasma concentrations were obtained in the two age groups, average maximum concentrations being 39.7 mg l-1 in those under 65 and 38.1 mg l-1 in the elderly. There were no significant differences in the half-life which averaged 30.4 and 32.1 h respectively. 3 Approximately 9% of all those studied had half-life values in excess of 50 h. The results are consistent with the possibility of genetic polymorphism of isoxicam hydroxylation. 4 It is concluded that isoxicam is suitable for use in once daily dosage and that there are no clinically significant differences in its pharmacokinetics between young and elderly subjects.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3620272-1260277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3620272-3983355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3620272-4640311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3620272-4815224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3620272-5569980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3620272-5764700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3620272-6122789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3620272-6148211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3620272-6391795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3620272-6411840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3620272-6462187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3620272-6508829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3620272-7084284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3620272-871632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3620272-871665
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0306-5251
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
22 Suppl 2
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
129S-134S
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:3620272-Adolescent,
pubmed-meshheading:3620272-Adult,
pubmed-meshheading:3620272-Aged,
pubmed-meshheading:3620272-Aging,
pubmed-meshheading:3620272-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:3620272-Female,
pubmed-meshheading:3620272-Half-Life,
pubmed-meshheading:3620272-Humans,
pubmed-meshheading:3620272-Kinetics,
pubmed-meshheading:3620272-Male,
pubmed-meshheading:3620272-Middle Aged,
pubmed-meshheading:3620272-Piroxicam
|
|
pubmed:year |
1986
|
|
pubmed:articleTitle |
A comparison of isoxicam pharmacokinetics in young and elderly subjects.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
