Linked Life Data

3618683

Source:http://linkedlifedata.com/resource/pubmed/id/3618683

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1987-9-23
pubmed:abstractText
We investigated the ability of human fetal membranes to produce progesterone from a variety of substrates. Chorion is more active than decidua, and amnion produces little progesterone. Cholesterol or low-density lipoprotein cholesterol was not used as a substrate. Chorion used pregnenolone, pregnenolone sulfate, and 20 alpha-dihydroprogesterone for progesterone synthesis. Decidua also used these three substrates but produced significantly less progesterone than chorion. Amnion used only 20 alpha-dihydroprogesterone as a substrate. Exogenous human chorionic gonadotropin or gonadotropin-releasing hormone or its analogues did not influence progesterone production by any of the tissues. There were several significant changes in substrate usage for progesterone synthesis by the tissues around the time of the onset of labor. Tissue concentrations of progesterone are approximately 4 ng/mg protein, and it appears that local production rates could completely account for this. These data are compatible with the hypothesis that local regulatory mechanisms may determine progesterone concentrations in fetal membrane tissues and that important changes may occur around the time of the onset of parturition.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0002-9378
pubmed:author
pubmed:issnType
Print
pubmed:volume
157
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
349-53
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Progesterone synthesis by human amnion, chorion, and decidua at term.
pubmed:publicationType
Journal Article, In Vitro