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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1976-6-2
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pubmed:abstractText |
The effect of doses of estradiol ranging from 0-0125 to 1-6 mug on the uterine weight of the spayed rat was studied 24 h after a single s.c. injection of the hormone. The lowest dose inducing a significant increase in uterine weight was 0-32 mug. When histamine dihydrochloride (50 mg) was simultaneously injected with the hormone, the effect of small doses of oestradiol (0-0125--0-2 mug) was significantly increased. When oestradiol and histamine were administered for 3 successive days, the uterine weight of animals receiving 0-0125 mug oestradiol, if compared with untreated controls, was increased only in the histamine-treated group. When 0-05 mug oestradiol was administered histamine did not modify the increase already produced by the hormone. Spermidine and burimamide, two substances structurally related to histamine, increased [3H]oestradiol uptake by the spayed rat uterus. The latter (an antihistamine drug acting on H2-receptors) as well as pyrathiazine (a histamine releaser having antihistamine properties) decreased the effect of histamine on oestradiol uptake whereas diphenhydramine (an antihistamine drug blocking H1-receptors) did not modify it. Pyrathiazine was itself able to diminish oestradiol uptake.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Burimamide,
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Histamine,
http://linkedlifedata.com/resource/pubmed/chemical/Histamine H1 Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Spermidine
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-0795
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
121-6
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:3616-Animals,
pubmed-meshheading:3616-Burimamide,
pubmed-meshheading:3616-Castration,
pubmed-meshheading:3616-Dose-Response Relationship, Drug,
pubmed-meshheading:3616-Drug Synergism,
pubmed-meshheading:3616-Estradiol,
pubmed-meshheading:3616-Female,
pubmed-meshheading:3616-Histamine,
pubmed-meshheading:3616-Histamine H1 Antagonists,
pubmed-meshheading:3616-Organ Size,
pubmed-meshheading:3616-Rats,
pubmed-meshheading:3616-Spermidine,
pubmed-meshheading:3616-Uterus
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pubmed:year |
1976
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pubmed:articleTitle |
Further evidence for histamine facilitating oestrogen action in the uterus.
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pubmed:publicationType |
Journal Article
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