Linked Life Data

3616570

Source:http://linkedlifedata.com/resource/pubmed/id/3616570

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1987-9-18
pubmed:abstractText
Video-enhanced differential interference contrast (VDIC) light microscopy in conjunction with fibrinogen labelled colloidal gold was employed as a probe to follow the mobility of the fibrinogen receptor on platelets. Correlative studies by both high voltage and scanning electron microscopy confirms localization of labels relative to platelet ultrastructural and surface characteristics, respectively. Treatment of platelets with trifluoperazine prior to and after incubation with fibrinogen-gold labels results in a concentration dependent inhibition of receptor movement. The results obtained from this study suggest that phosphorylation of myosin by the Ca++-calmodulin dependent enzyme, myosin-light chain kinase, is important in the fibrinogen redistribution that occurs during platelet activation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0891-7035
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
735-43
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Trifluoperazine inhibition of fibrinogen receptor redistribution in surface activated platelets: correlative video-enhanced differential interference contrast light microscopic, high voltage electron microscopic and scanning electron microscopic studies.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.