Linked Life Data

3612540

Source:http://linkedlifedata.com/resource/pubmed/id/3612540

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1987-8-31
pubmed:abstractText
The relative importance of descending serotonergic and noradrenergic pathways to the antinociceptive action of supraspinally and systemically administered morphine sulfate, and to the antinociceptive synergism observed between spinally and supraspinally administered morphine was examined in mice. Morphine administered i.c.v., intrathecally (i.t.), s.c. or i.t. + i.c.v. produced a dose-dependent antinociceptive response, as measured by the tail-flick test. The dose-response curve for morphine (i.c.v.) was shifted significantly to the right by equal i.t. doses of methysergide or phentolamine. However, the most pronounced shift to the right was caused by i.t. administration of the selective alpha-2 antagonist yohimbine. Administration of a subantinociceptive dose of morphine (i.t.) along with morphine (i.c.v.) shifted the dose-response curve for morphine (i.c.v.) 6-fold to the left. The resulting dose-response curve for morphine (i.c.v.) was shifted to the right more by phentolamine (i.t.) than by methysergide (i.t.). Similarly, the dose-response curve for morphine (s.c.) was shifted more to the right by phentolamine (i.t.) than by methysergide (i.t.). These results suggest that the descending noradrenergic system, more than the serotonergic system, may be an important component in spinal/supraspinal interactive mechanisms that may mediate the antinociceptive action of systemically administered morphine.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-3565
pubmed:author
pubmed:issnType
Print
pubmed:volume
242
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
90-5
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Central and systemic morphine-induced antinociception in mice: contribution of descending serotonergic and noradrenergic pathways.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.