Linked Life Data

3611429

Source:http://linkedlifedata.com/resource/pubmed/id/3611429

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1987-8-28
pubmed:abstractText
Morphometric analysis was carried out on electron micrographs of motor endplates from three Jack Russell terriers affected with congenital myasthenia gravis (CMG) aged 10 weeks, 12 weeks and 22 weeks, respectively. Control endplates from age-matched pups and an adult Jack Russell were also examined. The results showed that postsynaptic membrane density was significantly increased in affected animals and secondary fold length was decreased. The ratio of postsynaptic to presynaptic membrane length was normal in the 10 and 12-week-old pups, but reduced in the 22-week-old CMG animal. These changes were unrelated to muscle fibre diameter and there was no evidence of a destructive process. It is suggested that the alteration in membrane folding pattern in this condition may be related to abnormal trophic influences during synaptogenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0021-9975
pubmed:author
pubmed:issnType
Print
pubmed:volume
97
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
247-56
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Ultrastructure of motor endplates in canine congenital myasthenia gravis.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't