| pubmed-article:36110 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:36110 | lifeskim:mentions | umls-concept:C0025266 | lld:lifeskim |
| pubmed-article:36110 | lifeskim:mentions | umls-concept:C0521346 | lld:lifeskim |
| pubmed-article:36110 | lifeskim:mentions | umls-concept:C0007012 | lld:lifeskim |
| pubmed-article:36110 | lifeskim:mentions | umls-concept:C0242181 | lld:lifeskim |
| pubmed-article:36110 | lifeskim:mentions | umls-concept:C1441722 | lld:lifeskim |
| pubmed-article:36110 | lifeskim:mentions | umls-concept:C0681814 | lld:lifeskim |
| pubmed-article:36110 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:36110 | pubmed:dateCreated | 1979-7-16 | lld:pubmed |
| pubmed-article:36110 | pubmed:abstractText | Four respiratory analeptics were examined in a CO2 rebreathing experiment with increase from 0--6% in the inspiratory CO2 concentration during 30 min on 24 healthy young men. The respiratory response curves (VE/pCO2) showed a parabolic shape. They were examined on parallel shift and change of slope. The "excitability ratio" is the first derivative of the response parabola and as such becomes a linear function of the actual arterial CO2 partial pressure. The following effects have been shown: 1. 150 mg amiphenazole (2.07 mg/kg) cause a small rise in the ventilation by accelerating the frequency at increased CO2 partial pressures above 45 mmHg. 2. 240 mg theophylline ethylenediamine (3.32 mg/kg) produce a nearly parallel upward-shift of the respiratory response curve, i.e., the respiratory minute volume increases independently by a deepening of the respiration. 3. 450 mg prethcamide (6.22 mg/kg) cause a slight increase of the "excitability ratio" at CO2 partial pressures above 45 mmHg. The CO2-dependent respiratory minute volume is not changed significantly but the pattern of breathing changes by accelerating the frequency and decreasing the tidal volume. 4. 40 mg fominobene (0.55 mg/kg) raise the "excitability ratio" convincingly at CO2 partial pressures above 40 mmHg. However, the total volume ventilated during the experiment does not increase because of a diminished ventilation at rest. | lld:pubmed |
| pubmed-article:36110 | pubmed:language | eng | lld:pubmed |
| pubmed-article:36110 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:36110 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:36110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:36110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:36110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:36110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:36110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:36110 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:36110 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:36110 | pubmed:issn | 0004-4172 | lld:pubmed |
| pubmed-article:36110 | pubmed:author | pubmed-author:WiessmannK... | lld:pubmed |
| pubmed-article:36110 | pubmed:author | pubmed-author:BrossmannDD | lld:pubmed |
| pubmed-article:36110 | pubmed:author | pubmed-author:SteinijansV... | lld:pubmed |
| pubmed-article:36110 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:36110 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:36110 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:36110 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:36110 | pubmed:pagination | 329-33 | lld:pubmed |
| pubmed-article:36110 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:36110 | pubmed:meshHeading | pubmed-meshheading:36110-Hu... | lld:pubmed |
| pubmed-article:36110 | pubmed:meshHeading | pubmed-meshheading:36110-Th... | lld:pubmed |
| pubmed-article:36110 | pubmed:meshHeading | pubmed-meshheading:36110-Re... | lld:pubmed |
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| pubmed-article:36110 | pubmed:meshHeading | pubmed-meshheading:36110-Ce... | lld:pubmed |
| pubmed-article:36110 | pubmed:meshHeading | pubmed-meshheading:36110-Ca... | lld:pubmed |
| pubmed-article:36110 | pubmed:meshHeading | pubmed-meshheading:36110-Mo... | lld:pubmed |
| pubmed-article:36110 | pubmed:meshHeading | pubmed-meshheading:36110-Ma... | lld:pubmed |
| pubmed-article:36110 | pubmed:meshHeading | pubmed-meshheading:36110-Ad... | lld:pubmed |
| pubmed-article:36110 | pubmed:meshHeading | pubmed-meshheading:36110-Am... | lld:pubmed |
| pubmed-article:36110 | pubmed:meshHeading | pubmed-meshheading:36110-Ti... | lld:pubmed |
| pubmed-article:36110 | pubmed:meshHeading | pubmed-meshheading:36110-Bl... | lld:pubmed |
| pubmed-article:36110 | pubmed:year | 1979 | lld:pubmed |
| pubmed-article:36110 | pubmed:articleTitle | The efficacy of four respiratory analeptics on healthy young men in a CO2 rebreathing experiment. | lld:pubmed |
| pubmed-article:36110 | pubmed:publicationType | Journal Article | lld:pubmed |
