Linked Life Data

3610019

Source:http://linkedlifedata.com/resource/pubmed/id/3610019

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1987-8-28
pubmed:abstractText
Endotoxins have been suggested to be a factor in the pathophysiology of Crohn's disease (CD). We determined circulating antibodies against lipid A, a component common to endotoxins of gram-negative bacteria. Lipid A antibody titers in 91 patients with CD were significantly higher than in 56 patients with ulcerative colitis and 68 healthy subjects. In active CD lipid A antibodies were higher than in quiescent CD and markedly elevated titers of lipid A antibodies were associated with a severe course of CD. Duration, extent and localisation of CD showed no relationship to antibody titers against lipid A. Patients with prior bowel resection had a tendency towards lower antibody titers in comparison with non-operated patients. After total removal of inflamed bowel tissue, lipid A antibodies frequently disappeared. Medical therapy had different effects: prednisone and sulfasalazine did not influence antibody formation against lipid A, whereas antibody titers dropped significantly after therapy with ampicillin. These results confirm elevated circulating lipid A antibodies in patients with CD. Although it remains unclear whether lipid A antibodies are only an epiphenomenon in CD, on the basis of this clinical study further evidence is provided for the involvement of lipid A in the pathophysiology of CD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0172-6390
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
123-6
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Circulating lipid A antibodies and their relationship to different clinical conditions of patients with Crohn's disease.
pubmed:publicationType
Journal Article