Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1987-9-23
|
pubmed:abstractText |
Metabolism of 25-[3H]hydroxyvitamin D3 was studied in peritoneal macrophages from renal failure patients on continuous ambulatory peritoneal dialysis (CAPD). Cells from 5 out of 8 patients with a history of peritonitis produced significant amounts of a metabolite chromatographically identical to 1 alpha,25(OH)2D3; but none was produced by cells from non-infected patients. The evidence strongly suggests that peritoneal macrophages stimulated by infection can metabolise 25OHD3 to the active vitamin D3 metabolite, 1 alpha,25(OH)2D3, when maintained in short-term primary culture.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
0014-5793
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
17
|
pubmed:volume |
220
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
307-10
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:3609325-Calcifediol,
pubmed-meshheading:3609325-Calcitriol,
pubmed-meshheading:3609325-Chromatography, High Pressure Liquid,
pubmed-meshheading:3609325-Humans,
pubmed-meshheading:3609325-Kidney Failure, Chronic,
pubmed-meshheading:3609325-Macrophage Activation,
pubmed-meshheading:3609325-Macrophages,
pubmed-meshheading:3609325-Peritoneal Dialysis, Continuous Ambulatory,
pubmed-meshheading:3609325-Peritonitis
|
pubmed:year |
1987
|
pubmed:articleTitle |
Peritonitis induces the synthesis of 1 alpha,25-dihydroxyvitamin D3 in macrophages from CAPD patients.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|