Linked Life Data

3607434

Source:http://linkedlifedata.com/resource/pubmed/id/3607434

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1987-8-28
pubmed:abstractText
2-Decenoic acid, a fatty acid having 10 carbon atoms, blocks the action potentials of cultured dorsal root ganglion (DRG) neurons and this effect of 2-decenoic acid is reversible. From the analysis of the video pictures from Nomarski optics, relative values of the diameter and the thickness of the neurons increased to 1.06 and 1.14, respectively, when 2.1 mM 2-decenoic acid was applied to the neurons. The relative value of cell surface area, which was calculated from the equation for a spheroid, increased to about 1.20. On the other hand, relative fluorescence intensity of the fluorescent probe F18 (5-(octadecylthiocarbamoylamino)fluorescein) labeled neurons decreased to 0.81, when 2.1 mM 2-decenoic acid was applied to the neurons. This indicates that the relative cell surface area increased to 1.23, a value similar to that calculated from the results of the measurement of cell size. The time course of blocking action potentials after treatment of the fatty acid was similar to that of the cell membrane expansion. These results show that the fatty acid perturbs the cell membrane and expands the cell surface area and this expansion might reduce the opening ability of the Na+-channels in the membrane.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
411
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
298-303
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Cell membrane expansion and blockade of action potentials produced by 2-decenoic acid in cultured dorsal root ganglion neurons.
pubmed:publicationType
Journal Article