Linked Life Data

3601643

Source:http://linkedlifedata.com/resource/pubmed/id/3601643

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1987-7-29
pubmed:abstractText
Actions of Ca2+ antagonists (verapamil, nicardipine and diltiazem) on the voltage-dependent K+ current, obtained from the fragmented smooth muscle cell membrane (smooth muscle ball; SMB) of the rabbit small intestine, were investigated using voltage clamp techniques. To eliminate the influence of the Ca2+-dependent K+ current, the voltage-dependent K+ current was recorded in 2.5 mM Mn2+ (Ca2+ omitted) solution. These three Ca2+ antagonists inhibited the peak amplitude of the K+ current, in a dose-dependent manner. During application of a long command pulse (duration, 3 s), the amplitude of the voltage-dependent K+ current decreased slowly with time. Diltiazem inhibited the K+ current with a slight prolongation of the 20% decay time, while TEA (tetraethyl-ammonium), a K+ channel blocker, inhibited the current, without affecting the decay. By contrast, verapamil and nicardipine accelerated inactivation. In the control, the voltage-dependent inactivation was also seen in the K+ current. This inactivation curve below 0 mV was not modified by 10 microM diltiazem, 5 microM verapamil nor 3 microM nicardipine. These results indicate that inhibition of the voltage-dependent K+ current by verapamil or nicardipine differed from that by diltiazem.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0031-6768
pubmed:author
pubmed:issnType
Print
pubmed:volume
408
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
558-64
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Different inhibitions of the voltage-dependent K+ current by Ca2+ antagonists in the smooth muscle cell membrane of rabbit small intestine.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't