rdf:type |
|
lifeskim:mentions |
umls-concept:C0015127,
umls-concept:C0025255,
umls-concept:C0032343,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0039635,
umls-concept:C0227525,
umls-concept:C0442805,
umls-concept:C1150607,
umls-concept:C1306673,
umls-concept:C1314792,
umls-concept:C1515655
|
pubmed:issue |
4
|
pubmed:dateCreated |
1987-8-20
|
pubmed:abstractText |
TCDD was found to cause a significant rise in protein tyrosine kinase levels at an early stage of poisoning in rat liver membrane preparations. The results of sephadex G-150 column chromatographic analysis on rat hepatocyte membranes indicate that there are at least three tyrosine kinases of which activities increase as a consequence of TCDD treatment in vivo. The TCDD-evoked rise in such protein tyrosine kinase activity precedes the down-regulation of the EGF (epidermal growth factor) receptor in the plasma membrane in vivo.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
0024-3205
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
27
|
pubmed:volume |
41
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
429-36
|
pubmed:dateRevised |
2009-11-19
|
pubmed:meshHeading |
pubmed-meshheading:3600186-Animals,
pubmed-meshheading:3600186-Cell Membrane,
pubmed-meshheading:3600186-Dioxins,
pubmed-meshheading:3600186-Kinetics,
pubmed-meshheading:3600186-Liver,
pubmed-meshheading:3600186-Male,
pubmed-meshheading:3600186-Protein-Tyrosine Kinases,
pubmed-meshheading:3600186-Quercetin,
pubmed-meshheading:3600186-Rats,
pubmed-meshheading:3600186-Rats, Inbred Strains,
pubmed-meshheading:3600186-Receptor, Epidermal Growth Factor,
pubmed-meshheading:3600186-Tetrachlorodibenzodioxin
|
pubmed:year |
1987
|
pubmed:articleTitle |
TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) causes an increase in protein tyrosine kinase activities at an early stage of poisoning in vivo in rat hepatocyte membranes.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|