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Predicate | Object |
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rdf:type | |
lifeskim:mentions |
umls-concept:C0011945,
umls-concept:C0013030,
umls-concept:C0030685,
umls-concept:C0094913,
umls-concept:C0242485,
umls-concept:C0332120,
umls-concept:C0391871,
umls-concept:C0439851,
umls-concept:C0442111,
umls-concept:C0680255,
umls-concept:C0918012,
umls-concept:C1283071,
umls-concept:C1552596,
umls-concept:C1947931,
umls-concept:C1963578
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pubmed:issue |
1
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pubmed:dateCreated |
1987-7-29
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pubmed:abstractText |
Intracerebral dialysis was used to monitor the in vivo efflux of striatal dopamine (DA), homovanillic acid (HVA), dihydroxyphenylacetic acid (DOPAC) and 3-methoxytyramine (3-MT) in the pentobarbital anesthetized rat. In untreated rats, there were low levels of extra-cellular DA and 3-MT which were increased 15-fold by treatment with amphetamine. Under basal and drug-stimulated conditions, 3-MT concentrations were maintained at approximately 30% of the extracellular DA levels. These data agree with in vivo turnover estimates which indicate that 20 to 30% of DA turnover is through the 3-MT pool in the striatum. In contrast, extracellular DOPAC and HVA levels were reduced only slightly by amphetamine and with a delayed onset. Our data support the hypothesis that striatal DOPAC is an accurate index of intraneuronal DA metabolism and that 3-MT is an index of the extracellular concentration of DA.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0024-3205
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3600173-3,4-Dihydroxyphenylacetic Acid,
pubmed-meshheading:3600173-Animals,
pubmed-meshheading:3600173-Brain,
pubmed-meshheading:3600173-Dialysis,
pubmed-meshheading:3600173-Dopamine,
pubmed-meshheading:3600173-Homovanillic Acid,
pubmed-meshheading:3600173-Male,
pubmed-meshheading:3600173-Rats,
pubmed-meshheading:3600173-Synapses
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pubmed:year |
1987
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pubmed:articleTitle |
Intracerebral dialysis: direct evidence for the utility of 3-MT measurements as an index of dopamine release.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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