Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1987-8-13
pubmed:abstractText
Platelet-derived growth factor (PDGF) is a 30,000-Mr glycoprotein that is chemotactic and mitogenic for vascular smooth muscle cells (SMC). It is also a potent vasoconstrictor. In the present study, we found that the macrophage-derived polypeptide, tumor necrosis factor (TNF), releases a factor from human umbilical vein endothelial cells (EC) that is mitogenic for SMC. Postculture medium from TNF-stimulated EC induced a 90% increase in mitogenesis is compared with controls. This effect was half-maximal at a TNF dose of 114 pM, reflected a 2.5-fold increase in PDGF-specific mRNA synthesis, and peaked at 15 h of TNF stimulation. Mitogenic activity was completely abrogated by preincubation of postculture medium with antibody to platelet PDGF. Stimulation of EC with IL-1 (60-240 pM) led to the release of similar mitogenic activity. Thus, in addition to its effects on the hemostatic and adhesive properties of EC, TNF also promotes release of PDGF, which may serve to modulate proliferation of vascular SMC during wound healing, inflammation, and atherogenesis.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-2413547, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-2418059, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-2984061, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-2989820, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-2993897, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-2997166, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-2999289, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-2999773, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-3007500, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-3010124, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-3011946, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-3013421, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-3084701, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-3086483, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-3090105, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-3486418, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-3486658, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-3487091, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-3526909, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-3733873, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-3745161, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-3745265, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-3753996, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-3866246, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-3872118, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-3872925, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-3877078, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-3933111, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-4067416, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-4327464, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-4355998, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-518835, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-6088582, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-6090952, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-6300879, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-6318322, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-6322229, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-6332168, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-6369481, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-6490729, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-6635659, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-6885904, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-7038689, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-7309790, http://linkedlifedata.com/resource/pubmed/commentcorrection/3598461-7372716
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
166
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
235-45
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Tumor necrosis factor-mediated release of platelet-derived growth factor from cultured endothelial cells.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't