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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1987-8-4
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pubmed:abstractText |
The early proximal convoluted tubule (PCT) is the site of 50% of bicarbonate reabsorption in the nephron, but its control by angiotensin II has not been previously studied. In vivo microperfusion was used in both the early and late PCT in Munich-Wistar rats. Systemic angiotensin II administration (20 ng/kg X min) or inhibition of endogenous angiotensin II activity with saralasin (1 microgram/kg X min) caused profound changes in bicarbonate absorption in the early PCT (169 +/- 25 and -187 +/- 15 peq/mm X min, respectively). Because the bicarbonate absorptive capacity of the early PCT under free-flow conditions is 500 peq/mm X min, angiotensin II administration or inhibition affected greater than 60% of proton secretion in this segment. Both agents less markedly affected bicarbonate absorption in the late PCT (+/- 28 peq/mm X min) or chloride absorption (+/- 68-99 peq/mm X min) in both the early and late PCT. Because of its potential for controlling the majority of bicarbonate absorption in the early PCT (hence greater than or equal to 30% of bicarbonate absorption in the entire nephron), angiotensin II may be a powerful physiologic regulator of renal acidification.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3597776-1254727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3597776-23967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3597776-3003153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3597776-3782470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3597776-3887946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3597776-4011403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3597776-457865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3597776-5333381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3597776-556854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3597776-6267106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3597776-6300146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3597776-6303754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3597776-6368101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3597776-6693796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3597776-6696082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3597776-6699174
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
80
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
272-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3597776-Absorption,
pubmed-meshheading:3597776-Angiotensin II,
pubmed-meshheading:3597776-Animals,
pubmed-meshheading:3597776-Bicarbonates,
pubmed-meshheading:3597776-Chlorides,
pubmed-meshheading:3597776-Hydrogen-Ion Concentration,
pubmed-meshheading:3597776-Kidney Tubules, Proximal,
pubmed-meshheading:3597776-Kinetics,
pubmed-meshheading:3597776-Male,
pubmed-meshheading:3597776-Rats,
pubmed-meshheading:3597776-Rats, Inbred Strains,
pubmed-meshheading:3597776-Saralasin
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pubmed:year |
1987
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pubmed:articleTitle |
Angiotensin II: a potent regulator of acidification in the rat early proximal convoluted tubule.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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