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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
7
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pubmed:dateCreated |
1987-8-4
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pubmed:abstractText |
Albino mice of different inbred strains have been exposed to constant fluorescent lighting at an illuminance level of 115-130 ft-c for intervals of 1-6 weeks. Under these conditions the photoreceptors in retinas of albino BALB/cByJ mice rapidly degenerate, whereas the photoreceptors in retinas of albino C57BL/6J-c2J mice are remarkably more resistant to light damage. F1 heterozygotes produced from these two strains display an intermediate degree of light-induced degeneration. These findings demonstrate that phenotypically identical populations with different genetic constitutions can show markedly different sensitivities to light, and that genetic factors must now be included as a determinant for the severity of light damage.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
|
pubmed:issn |
0146-0404
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1043-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:3596986-Animals,
pubmed-meshheading:3596986-Female,
pubmed-meshheading:3596986-Genes, Regulator,
pubmed-meshheading:3596986-Heterozygote,
pubmed-meshheading:3596986-Light,
pubmed-meshheading:3596986-Male,
pubmed-meshheading:3596986-Mice,
pubmed-meshheading:3596986-Mice, Inbred BALB C,
pubmed-meshheading:3596986-Mice, Inbred C57BL,
pubmed-meshheading:3596986-Phenotype,
pubmed-meshheading:3596986-Photoreceptor Cells,
pubmed-meshheading:3596986-Radiation Injuries, Experimental,
pubmed-meshheading:3596986-Rats,
pubmed-meshheading:3596986-Retina,
pubmed-meshheading:3596986-Retinal Degeneration
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pubmed:year |
1987
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pubmed:articleTitle |
Genetic regulation of light damage to photoreceptors.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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