Linked Life Data

3596804

Source:http://linkedlifedata.com/resource/pubmed/id/3596804

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:3596804rdf:typepubmed:Citationlld:pubmed
pubmed-article:3596804lifeskim:mentionsumls-concept:C0205474lld:lifeskim
pubmed-article:3596804lifeskim:mentionsumls-concept:C0001271lld:lifeskim
pubmed-article:3596804lifeskim:mentionsumls-concept:C1280500lld:lifeskim
pubmed-article:3596804lifeskim:mentionsumls-concept:C1446994lld:lifeskim
pubmed-article:3596804lifeskim:mentionsumls-concept:C1533691lld:lifeskim
pubmed-article:3596804lifeskim:mentionsumls-concept:C2603343lld:lifeskim
pubmed-article:3596804lifeskim:mentionsumls-concept:C1515655lld:lifeskim
pubmed-article:3596804pubmed:issue7lld:pubmed
pubmed-article:3596804pubmed:dateCreated1987-7-29lld:pubmed
pubmed-article:3596804pubmed:abstractTextWe describe a simplified procedure for purification of Clostridium difficile toxin B. In this procedure, cytotoxicity is associated with a single protein band with a molecular mass of 230 kilodaltons. We used direct fluorescent staining of actin filaments to study the effect of this toxin on cultured cells. Morphologic changes were preceded by a decrease in the number and length of stress fibers followed by their disappearance with condensation of cellular actin around the nucleus. We then showed that cells treated with either cytochalasin B or toxin B had a significant increase in the monomeric actin pool as quantitated by DNase I inhibition. In contrast to the cytochalasins, toxin B had no direct effect on the rate or extent of actin polymerization or network formation in vitro. Cytoplasmic extracts of toxin B-treated cells had a significantly lower level of modulating activity on actin assembly and interactions in vitro compared with extracts of untreated cells. These results suggest that the action of toxin B on cells is due to direct or indirect effects on cellular proteins involved in controlling the state of actin assembly in the cells.lld:pubmed
pubmed-article:3596804pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3596804pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3596804pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3596804pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3596804pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3596804pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3596804pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3596804pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3596804pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3596804pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3596804pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3596804pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3596804pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3596804pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3596804pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3596804pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3596804pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3596804pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3596804pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3596804pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3596804pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3596804pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3596804pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3596804pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3596804pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3596804pubmed:languageenglld:pubmed
pubmed-article:3596804pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3596804pubmed:citationSubsetIMlld:pubmed
pubmed-article:3596804pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3596804pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3596804pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3596804pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:3596804pubmed:statusMEDLINElld:pubmed
pubmed-article:3596804pubmed:monthJullld:pubmed
pubmed-article:3596804pubmed:issn0019-9567lld:pubmed
pubmed-article:3596804pubmed:authorpubmed-author:LimRRlld:pubmed
pubmed-article:3596804pubmed:authorpubmed-author:LaughonB EBElld:pubmed
pubmed-article:3596804pubmed:authorpubmed-author:MitchellM JMJlld:pubmed
pubmed-article:3596804pubmed:issnTypePrintlld:pubmed
pubmed-article:3596804pubmed:volume55lld:pubmed
pubmed-article:3596804pubmed:ownerNLMlld:pubmed
pubmed-article:3596804pubmed:authorsCompleteYlld:pubmed
pubmed-article:3596804pubmed:pagination1610-5lld:pubmed
pubmed-article:3596804pubmed:dateRevised2011-11-17lld:pubmed
pubmed-article:3596804pubmed:meshHeadingpubmed-meshheading:3596804-...lld:pubmed
pubmed-article:3596804pubmed:meshHeadingpubmed-meshheading:3596804-...lld:pubmed
pubmed-article:3596804pubmed:meshHeadingpubmed-meshheading:3596804-...lld:pubmed
pubmed-article:3596804pubmed:meshHeadingpubmed-meshheading:3596804-...lld:pubmed
pubmed-article:3596804pubmed:meshHeadingpubmed-meshheading:3596804-...lld:pubmed
pubmed-article:3596804pubmed:meshHeadingpubmed-meshheading:3596804-...lld:pubmed
pubmed-article:3596804pubmed:meshHeadingpubmed-meshheading:3596804-...lld:pubmed
pubmed-article:3596804pubmed:meshHeadingpubmed-meshheading:3596804-...lld:pubmed
pubmed-article:3596804pubmed:meshHeadingpubmed-meshheading:3596804-...lld:pubmed
pubmed-article:3596804pubmed:meshHeadingpubmed-meshheading:3596804-...lld:pubmed
pubmed-article:3596804pubmed:year1987lld:pubmed
pubmed-article:3596804pubmed:articleTitleBiochemical studies on the effect of Clostridium difficile toxin B on actin in vivo and in vitro.lld:pubmed
pubmed-article:3596804pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:3596804pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3596804lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3596804lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3596804lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3596804lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3596804lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3596804lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3596804lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3596804lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3596804lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3596804lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3596804lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3596804lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3596804lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:3596804lld:pubmed