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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1987-8-12
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pubmed:abstractText |
This study has investigated whether natural killer (NK) cells play a protective or an effector role in unirradiated mice with graft-versus-host reaction (GvHR). Treatment of (CBA X BALB/c)F1 mice with anti-asialo GM1 (ASGM1) antibody produced a profound depletion of resting NK-cell activity and also inhibited the normal enhancement of NK activity found after induction of a GvHR with CBA spleen cells. Compared with normal hosts, mice treated with anti-AsGM1 developed less splenomegaly in GvHR and did not show the crypt hyperplasia normally found in this model of GvHR. Anti-AsGM1 also produced a small but significant reduction of intraepithelial lymphocyte (IEL) numbers in the jejunum of control mice. We conclude that intestinal NK cells are an essential component of the local delayed-type hypersensitivity (DTH) reaction which is responsible for the intestinal phase of GvHR in unirradiated mice.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3596637-14866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3596637-2428733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3596637-2579898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3596637-2935486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3596637-2936802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3596637-3005395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3596637-304463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3596637-3098677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3596637-336380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3596637-3484848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3596637-3486908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3596637-3531381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3596637-3876371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3596637-3905963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3596637-3958492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3596637-4070976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3596637-6195261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3596637-6294182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3596637-6343094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3596637-6355291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3596637-6604089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3596637-6605602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3596637-6966574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3596637-6974420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3596637-6979490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3596637-7000893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3596637-7135468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3596637-7240748
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
179-83
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3596637-Animals,
pubmed-meshheading:3596637-Cytotoxicity, Immunologic,
pubmed-meshheading:3596637-G(M1) Ganglioside,
pubmed-meshheading:3596637-Glycosphingolipids,
pubmed-meshheading:3596637-Graft vs Host Reaction,
pubmed-meshheading:3596637-Hypersensitivity, Delayed,
pubmed-meshheading:3596637-Jejunum,
pubmed-meshheading:3596637-Killer Cells, Natural,
pubmed-meshheading:3596637-Mice,
pubmed-meshheading:3596637-Mice, Inbred BALB C,
pubmed-meshheading:3596637-Mice, Inbred CBA,
pubmed-meshheading:3596637-Spleen
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pubmed:year |
1987
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pubmed:articleTitle |
Experimental studies of immunologically mediated enteropathy. II. Role of natural killer cells in the intestinal phase of murine graft-versus-host reaction.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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