rdf:type |
|
lifeskim:mentions |
umls-concept:C0001480,
umls-concept:C0003842,
umls-concept:C0030685,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0205097,
umls-concept:C0205227,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1963578
|
pubmed:issue |
3
|
pubmed:dateCreated |
1987-7-28
|
pubmed:abstractText |
Electrical field stimulation of the rat caudal artery (0.5-ms pulses at 8 Hz for 3 min) results in the release of norepinephrine (quantified by HPLC-electrochemical detection) and adenyl purines including ATP, ADP and AMP (quantified by HPLC-fluorescence detection). The amount of ATP released from the tissue exceeded the amount of norepinephrine. Because postjunctional alpha 1-adrenoceptor stimulation with methoxamine also causes release of ATP, both neuronal and extraneuronal sites may contribute to the overflow of ATP. Results with the alpha 1-adrenoceptor antagonist prazosin lend support to this notion. Prazosin (10(-6) M) completely blocked the release of ATP by methoxamine but only partially reduced the release of ATP by field stimulation.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:issn |
0303-6847
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
24
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
125-7
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:3593975-Adenosine Diphosphate,
pubmed-meshheading:3593975-Adenosine Monophosphate,
pubmed-meshheading:3593975-Adenosine Triphosphate,
pubmed-meshheading:3593975-Animals,
pubmed-meshheading:3593975-Arteries,
pubmed-meshheading:3593975-Electric Stimulation,
pubmed-meshheading:3593975-Norepinephrine,
pubmed-meshheading:3593975-Osmolar Concentration,
pubmed-meshheading:3593975-Purines,
pubmed-meshheading:3593975-Rats,
pubmed-meshheading:3593975-Tail
|
pubmed:year |
1987
|
pubmed:articleTitle |
Release of endogenous ATP from rat caudal artery.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|