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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1987-8-14
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pubmed:abstractText |
Five patients with heterozygous beta-thalassaemia with an unusually severe clinical picture, low haemoglobin levels occasionally requiring blood transfusion, splenomegaly and unusually prominent basophilic stippling were found to have co-inherited a triple alpha-globin gene arrangement on one chromosome (alpha alpha alpha/alpha alpha). It seems probable that the expression of a single extra alpha-globin gene is sufficient in some patients with heterozygous beta-thalassaemia to give rise to a clinically significant degree of dyserythropoietic anaemia.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0007-1048
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
109-12
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:3593645-Adult,
pubmed-meshheading:3593645-Female,
pubmed-meshheading:3593645-Globins,
pubmed-meshheading:3593645-Heterozygote,
pubmed-meshheading:3593645-Humans,
pubmed-meshheading:3593645-Male,
pubmed-meshheading:3593645-Multigene Family,
pubmed-meshheading:3593645-Phenotype,
pubmed-meshheading:3593645-Thalassemia
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pubmed:year |
1987
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pubmed:articleTitle |
Thalassaemia intermedia: interaction of the triple alpha-globin gene arrangement and heterozygous beta-thalassaemia.
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pubmed:publicationType |
Journal Article,
Case Reports
|