Linked Life Data

3592206

Source:http://linkedlifedata.com/resource/pubmed/id/3592206

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1987-6-29
pubmed:abstractText
Acute changes involving the hormones thyroxine (T4) and triiodothyronine (T3) followed by hyper -or hypothyroid crises will lead to both cardiovascular and metabolic disorders. Due to highly sensitive mechanisms controlling central hormonal production and peripheral enzymatic conversion (c.g. T4 to T3), numerous pharmacologically effective substances will influence the kinetics of these hormones. Thus, agents routinely used in anesthetic practice and their metabolites may disturb hormonal regulation in particular due to their central effectiveness [1, 2,5-7]. Based on this premise, it was our goal to search for anesthetic-induced hormonal changes in euthyroid patients living in a goiter-endemic area scheduled for short, elective orthopedic operations. Investigations were done in 21 outpatients (mean age: 24 years, mean body wt.: 64 kg) undergoing minor surgical procedures of the extremities. No clinical signs of thyroid disturbances could be observed preoperatively in the patients. Immediately after intravenous premedication (meperidine HCl 0.75 mg/kg and atropine 0.25 mg), anesthesia was induced (thiopentone 5 mg/kg) and continued by inhalation via face; mask using volatile agents: halothane, isoflurane, or enflurane (O2: N2O; FiO2 = 0.33). According to the anesthetic agent administered (halothane, isoflurane, enflurane), patients were divided into three groups of 7 patients each as listed in Table 1. Blood samples to determine free serum T4 (fT4) and T3 (fT3) as an expression of biologically available T4/T3, unconjugated to transport globulins, were drawn twice: immediately before premedication; and postoperatively after the patient had regained consciousness.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0003-2417
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
132-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
[The behavior of free thyroxine and triiodothyronine concentrations after short-term balanced inhalation anesthesia].
pubmed:publicationType
Journal Article, English Abstract