Linked Life Data

3588521

Source:http://linkedlifedata.com/resource/pubmed/id/3588521

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1987-7-8
pubmed:abstractText
The action of lithium on calcium-calmodulin-activated and forskolin-activated catalytic unit of adenylate cyclase has been studied. The catalytic unit was solubilized from rat brain and separated from the guanine nucleotide binding protein by gel filtration. Calcium-calmodulin-stimulated and forskolin-stimulated catalytic unit activities were inhibited in the presence of 2 mM and 1 mM of lithium, respectively. No inhibitory effect was observed on the basal activity. The inhibitory effect of lithium on the stimulated activities was antagonized by magnesium. Lithium did not influence the interaction of the enzyme substrate (ATP) with the catalytic unit. The present results indicate that lithium interacts directly with the catalytic unit of the adenylate cyclase system. In the neuron, lithium might interfere with a divalent cation site on the catalytic unit.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0901-9928
pubmed:author
pubmed:issnType
Print
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
241-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Mode of action of lithium on the catalytic unit of adenylate cyclase from rat brain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't