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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1987-7-2
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pubmed:abstractText |
The conformation of the double-stranded, mixed ribodeoxyribo polynucleotide, poly (rG-dC).poly (rG-dC), has been examined in the presence of tetraalkyl ammonium ions. Tetramethyl ammonium ion stabilizes the "low salt" Z conformation (1) of the polymer from submillimolar to molar concentrations of the counterion. In the presence of tetraethyl and tetrapropyl ammonium ions the polymer exists in the low salt Z form up to 2 mM concentration of the counterions and then flips to the right hand helical A form. With tetrabutyl ammonium counterions the polymer is in an A conformation at low ion concentrations and converts to a B form at concentrations greater than thirty millimolar. These results are interpreted in terms of electrostatic and solvent interactions of the polynucleotide.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3588312-353876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3588312-3856838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3588312-3892484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3588312-4346879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3588312-4897330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3588312-653353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3588312-6574457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3588312-6594692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3588312-6626529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3588312-6834428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3588312-6941264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3588312-6946428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3588312-7071593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3588312-7225341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3588312-7463477
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0305-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3907-16
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3588312-Chemistry, Physical,
pubmed-meshheading:3588312-Circular Dichroism,
pubmed-meshheading:3588312-DNA,
pubmed-meshheading:3588312-Nucleic Acid Conformation,
pubmed-meshheading:3588312-Oligodeoxyribonucleotides,
pubmed-meshheading:3588312-Oligoribonucleotides,
pubmed-meshheading:3588312-Physicochemical Phenomena,
pubmed-meshheading:3588312-Quaternary Ammonium Compounds,
pubmed-meshheading:3588312-Tetraethylammonium,
pubmed-meshheading:3588312-Tetraethylammonium Compounds
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pubmed:year |
1987
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pubmed:articleTitle |
Influence of tetraalkyl ammonium ions on the structure of poly (rG-dC).poly (rG-dC): unexpected transitions among the Z, A and B conformations.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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