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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1987-7-9
|
| pubmed:abstractText |
Several 1,2-dihydro-5-(substituted phenyl)-2(1H)-pyridinones were synthesized and evaluated for inotropic activity. 1,2-Dihydro-5-[4-(1H-imidazol-1-yl)phenyl]-6-methyl-2-oxo-3- pyridinecarbonitrile (5a) and the corresponding unsubstituted analogue 14a were the most potent positive inotropic agents in this series. Although the 4,6-dimethyl analogue 6a retained most of the activity of 5a, the 4-methyl analogue 8a was substantially less potent. The synthesis and structure-activity relationships are discussed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
30
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1023-9
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:3585900-Animals,
pubmed-meshheading:3585900-Cardiotonic Agents,
pubmed-meshheading:3585900-Dogs,
pubmed-meshheading:3585900-Dose-Response Relationship, Drug,
pubmed-meshheading:3585900-Female,
pubmed-meshheading:3585900-Imidazoles,
pubmed-meshheading:3585900-Male,
pubmed-meshheading:3585900-Myocardial Contraction,
pubmed-meshheading:3585900-Nitriles,
pubmed-meshheading:3585900-Pyridones,
pubmed-meshheading:3585900-Structure-Activity Relationship
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
Cardiotonic agents. 5. 1,2-Dihydro-5-[4-(1H-imidazol-1-yl)phenyl]-6-methyl-2-oxo-3- pyridinecarbonitriles and related compounds. Synthesis and inotropic activity.
|
| pubmed:publicationType |
Journal Article
|