Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1987-6-26
pubmed:abstractText
A method for the volumetric assessment of early cerebral infarction, together with its statistical and biological validation, is described. In halothane anaesthetised rats the stem of the right middle cerebral artery was occluded and 3 hours later (with full monitoring of respiratory and cardiovascular status) the animals were killed by perfusion fixation. In normotensive normocapnic animals the volume of infarction was 52 +/- 4 mm3 in the cerebral cortex and 21 +/- 1 mm3 in the corpus striatum. The reproducibility of the volumetric assessment was found to be excellent (coefficient of correlation 0.995 on 18 replicate measurements). The minimum number of stereotactic levels which must be assessed to yield accurate volumetric measurements of infarction is 8. The method is sensitive at detecting alterations in the amount of infarction. For example, it can readily detect the increase in amount of structural damage in cerebral cortex following a transient episode of hypotension. This approach allows an objective assessment of drug therapy and management strategies in the treatment of cerebral infarction.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-1111180, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-1159477, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-1180003, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-1219085, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-1258104, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-13939773, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-14416289, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-27884, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-3711159, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-3936403, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-4012559, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-409738, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-4117325, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-4209598, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-442136, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-443769, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-462512, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-4640167, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-4728181, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-4728182, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-4811308, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-5001802, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-5001842, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-5646472, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-5906190, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-5928981, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-644608, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-644622, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-6464064, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-6464065, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-6498494, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-6507048, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-6742790, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-7086511, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-7096456, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-7103425, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-7137595, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-7189431, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-7262125, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-7303075, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-7328138, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-7328139, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-7414661, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-808760, http://linkedlifedata.com/resource/pubmed/commentcorrection/3585350-817699
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0022-3050
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
402-10
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Quantitative assessment of early brain damage in a rat model of focal cerebral ischaemia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't