Linked Life Data

3585142

Source:http://linkedlifedata.com/resource/pubmed/id/3585142

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1987-7-16
pubmed:abstractText
The surface active material (SAM) of alveolar lining fluid has been shown to have immunologic activity. We studied the effect of SAM on monocyte-macrophage cytotoxicity against a tumor cell line. Alveolar macrophages were studied from 15 subjects without cancer. Tumor growth, as assessed by tritiated thymidine incorporation, was significantly inhibited by the macrophages alone (tumor alone median 39,401 cpm, macrophages plus tumor median 12,153 cpm, P less than 0.01). Tumor cytotoxicity was enhanced by preincubating the macrophages with lipopolysaccharide (median 37 cpm, P less than 0.01) or coincubating the tumor cells and macrophages with SAM (median 5474 cpm, P less than 0.01). Similar results were seen when using blood adherent mononuclear cells. There was increasing cytotoxicity for the adherent mononuclear cells with increasing amounts of SAM. When the various phospholipids of SAM were studied, it was found that phosphatidylcholine, sphingomyelin, and phosphatidyl glycerol all enhanced adherent mononuclear cell cytotoxicity, whereas phosphatidylinositol inhibited adherent mononuclear cell cytotoxicity. These studies suggest that SAM may have important immunoregulatory function for the alveolar macrophage.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-2143
pubmed:author
pubmed:issnType
Print
pubmed:volume
109
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
692-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Enhancement of macrophage and monocyte cytotoxicity by the surface active material of lung lining fluid.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't