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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1987-7-16
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pubmed:abstractText |
The method presented here is based on the ability of ethambutol to give chelates with divalent cationic metals. With copper salts, the chelate presents a characteristic ultraviolet absorbance at 270 nm, making it possible to titrate ethambutol extracted from plasma with chloroform in alkaline medium. The column which was used contained silica (LiChrosorb Si 60, 5 microns) and the mobile phase was a mixture of equal parts of water and acetonitrile, containing copper sulphate and ammonia. The internal standard was a lower homologue of ethambutol with the same chelating ability. The detection limit was 0.15 mg/l. No interference with other antitubercular agents was observed.
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pubmed:language |
fre
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0021-9673
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
415
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
85-94
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3584365-Ammonia,
pubmed-meshheading:3584365-Chromatography, Gel,
pubmed-meshheading:3584365-Chromatography, Liquid,
pubmed-meshheading:3584365-Copper,
pubmed-meshheading:3584365-Ethambutol,
pubmed-meshheading:3584365-Humans,
pubmed-meshheading:3584365-Spectrophotometry, Ultraviolet
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pubmed:year |
1987
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pubmed:articleTitle |
[Determination of plasma ethambutol with liquid chromatography and ultraviolet spectrophotometry].
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pubmed:publicationType |
Journal Article,
English Abstract
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