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Predicate | Object |
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rdf:type | |
lifeskim:mentions |
umls-concept:C0015219,
umls-concept:C0015576,
umls-concept:C0015879,
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0023693,
umls-concept:C0033799,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0162326,
umls-concept:C0205147,
umls-concept:C1171362,
umls-concept:C1515670,
umls-concept:C1711351,
umls-concept:C1880022,
umls-concept:C2347858
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pubmed:issue |
15
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pubmed:dateCreated |
1987-6-26
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pubmed:databankReference | |
pubmed:abstractText |
The iron storage protein ferritin consists of two types of subunits of different molecular weight, heavy (H) and light (L). The rat genome contains approximately 20 copies of the ferritin L-subunit gene, of which we have sequenced seven. One is an expressed ferritin gene containing three introns located between the alpha-helical domains of the L-subunit protein. The remaining six have the characteristics of processed pseudogenes. Sequence divergence suggest that these pseudogenes arose approximately 3-12 X 10(6) years ago, well within the 30 X 10(6) years of divergence of rat and mouse. By using intron probes derived from the expressed ferritin L-gene, a homologous second copy has been identified in some Fischer rats. Comparison of the 5'-untranslated region of the rat L-gene with the published sequences of this region of the human L (Santoro, C., Marone, M., Ferrone, M., Costanzo, F., Colombo, M., Minganti, C., Cortese, R., and Silengo, L. (1986) Nucleic Acids Res. 14, 2863-2876) and H (Costanzo, F., Colombo, M., Staempfli, S., Santoro, C., Marone, M., Frank, R., Delius, H., and Cortese, R. (1986) Nucleic Acids Res. 14, 721-735) genes and of a bullfrog cDNA (Didsbury, J. R., Theil, E. C., Kaufman, R. E., and Dickey, L. F. (1986) J. Biol. Chem. 261, 949-955) show a strongly conserved 28-base pair sequence, suggesting a translational regulatory function. The 5' flanking region of the rat L-gene contains sequences homologous to those in the flanking areas of the human L- and H-genes. The implications of these conserved sequences for control of ferritin expression are discussed.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0021-9258
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
262
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7335-41
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:3584116-Amino Acid Sequence,
pubmed-meshheading:3584116-Animals,
pubmed-meshheading:3584116-Base Sequence,
pubmed-meshheading:3584116-Biological Evolution,
pubmed-meshheading:3584116-DNA,
pubmed-meshheading:3584116-DNA, Recombinant,
pubmed-meshheading:3584116-Ferritins,
pubmed-meshheading:3584116-Humans,
pubmed-meshheading:3584116-Introns,
pubmed-meshheading:3584116-Molecular Weight,
pubmed-meshheading:3584116-Nucleic Acid Hybridization,
pubmed-meshheading:3584116-Protein Biosynthesis,
pubmed-meshheading:3584116-Rats,
pubmed-meshheading:3584116-Rats, Inbred Strains
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pubmed:year |
1987
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pubmed:articleTitle |
Characterization and evolution of the expressed rat ferritin light subunit gene and its pseudogene family. Conservation of sequences within noncoding regions of ferritin genes.
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pubmed:publicationType |
Journal Article,
Comparative Study
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