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Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
|
pubmed:dateCreated |
1987-7-16
|
pubmed:abstractText |
Midazolam given as hourly intermittent injections was compared with the same dose given by infusion for postoperative sedation in patients after cardiopulmonary bypass. A stable concentration was rapidly attained with the infusion whereas 6-8 h was required to attain stable plasma (trough) concentrations in the intermittent injection group. Plasma concentrations decreased rapidly to low values within 6 h of discontinuation of therapy. High plasma concentrations and a long (16 h) half-life were noted in one patient who may be a slow metabolizer of the drug.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
0007-0912
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
59
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
557-60
|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3580237-Adult,
pubmed-meshheading:3580237-Cardiac Surgical Procedures,
pubmed-meshheading:3580237-Half-Life,
pubmed-meshheading:3580237-Humans,
pubmed-meshheading:3580237-Hypnotics and Sedatives,
pubmed-meshheading:3580237-Kinetics,
pubmed-meshheading:3580237-Midazolam,
pubmed-meshheading:3580237-Postoperative Care
|
pubmed:year |
1987
|
pubmed:articleTitle |
Midazolam sedation following open heart surgery.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|