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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1979-7-25
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pubmed:abstractText |
A search was made in sympathetic ganglia of the bullfrog for a noncholinergic, nonaminergic transmitter that is released by a distinct group of preganglionic axons. These initiate a late slow excitatory postsynaptic potential which lasts for many minutes. The most promising candidate for the role of transmitter is a peptide that resembles luteinizing hormone-releasing hormone (LHRH; luliberin). The reasons are: (i) LHRH (1 muM) and some of its analogs cause a slow depolarization of ganglion cells. (ii) Radioimmunoassays established that 100-800 pg of a LHRH-like substance is contained in the lumbar chain of sympathetic ganglia. (iii) The LHRH-like material is specifically distributed in those spinal nerves that contain axons that initiate the slow noncholinergic synaptic responses. (iv) Five days after ipsilateral preganglionic axons are cut, 95% of the LHRH-like substance disappears from ganglia, while the LHRH immunoreactivity triples in the spinal nerves proximal to the cut region. (v) About 0.6% of the LHRH-like material within ganglia can be collected from the perfusate after 30 min of incubation in isotonic KC1; this release is Ca dependent. (vi) The candidate for transmitter has several chemical characteristics of a peptide and has a Mr near 1000.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/35789-12473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/35789-13278921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/35789-164261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/35789-16994545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/35789-17359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/35789-212832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/35789-329951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/35789-332491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/35789-4295893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/35789-4301231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/35789-4303837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/35789-4351520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/35789-4396517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/35789-4546163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/35789-4572738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/35789-4591652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/35789-5857909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/35789-626889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/35789-672964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/35789-99816
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1501-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1979
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pubmed:articleTitle |
A peptide as a possible transmitter in sympathetic ganglia of the frog.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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