Linked Life Data

3578401

Source:http://linkedlifedata.com/resource/pubmed/id/3578401

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1987-5-29
pubmed:abstractText
The effect of seven low-dose oral contraceptive preparations on carbohydrate metabolism was investigated in groups of 10 healthy volunteers. All preparations contained a similar amount of ethinyl estradiol but differed in the content and type of progestogen. The following progestogens were used: levonorgestrel (monophasic and triphasic), norethisterone (monophasic), cyproterone acetate (monophasic), desogestrel (monophasic and biphasic) and gestodene (triphasic). An oral glucose tolerance test was performed before and after 6 months of treatment; glucose disappearance and insulin response curve were determined. Long-term glucose homeostasis was assessed by the estimation of the extent of glycosylation of plasma proteins and hemoglobin A1. The area under the curve for insulin and glucose did not change during treatment with any of the preparations. In addition the representative variables for long-term glucose control did not increase for any of the preparations during treatment. We conclude from these results that the low-dose pills investigated in this study do not have any adverse effects on glucose metabolism after treatment for 6 months.
pubmed:keyword
http://linkedlifedata.com/resource/pubmed/keyword/Biology, http://linkedlifedata.com/resource/pubmed/keyword/Carbohydrate Metabolic Effects, http://linkedlifedata.com/resource/pubmed/keyword/Clinical Research, http://linkedlifedata.com/resource/pubmed/keyword/Contraception, http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents, http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents, Female, http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Methods--side effects, http://linkedlifedata.com/resource/pubmed/keyword/Developed Countries, http://linkedlifedata.com/resource/pubmed/keyword/Diseases, http://linkedlifedata.com/resource/pubmed/keyword/Economic Factors, http://linkedlifedata.com/resource/pubmed/keyword/Europe, http://linkedlifedata.com/resource/pubmed/keyword/Evaluation, http://linkedlifedata.com/resource/pubmed/keyword/Family Planning, http://linkedlifedata.com/resource/pubmed/keyword/Metabolic Effects, http://linkedlifedata.com/resource/pubmed/keyword/NETHERLANDS, http://linkedlifedata.com/resource/pubmed/keyword/Oral Contraceptives, Low-dose--side..., http://linkedlifedata.com/resource/pubmed/keyword/Oral Contraceptives--side effects, http://linkedlifedata.com/resource/pubmed/keyword/Physiology, http://linkedlifedata.com/resource/pubmed/keyword/Research And Development, http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology, http://linkedlifedata.com/resource/pubmed/keyword/TECHNOLOGY, http://linkedlifedata.com/resource/pubmed/keyword/Western Europe
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0002-9378
pubmed:author
pubmed:issnType
Print
pubmed:volume
156
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
918-22
pubmed:dateRevised
2006-11-15
pubmed:otherAbstract
PIP: 70 healthy female volunteers participated in a study designed to investigate the effect of 7 low-dose oral contraceptive (OC) preparations on carbohydrate metabolism. The study participants were divided randomly into 7 groups (10 volunteers per group), each receiving 1 of the preparations. Table 1 presents the composition and intake regimen of the various preparations. The treatment period lasted 6 cycles; each cycle consisted of 21 days of tablet intake followed by 7 tablet-free days. An oral glucose challenge test was performed. It was carried out during the luteal phase of the control cycle (days 19-24) and on day 15 or 19 of the 6th treatment cycle. Blood samples were taken after overnight fasting (12-15 hours) just before the glucose loading and 30, 60, 120, and 180 minutes after glucose intake. Glucose was determined with the glucose-oxidase method on a Beckman glucose analyzer, and insulin was assayed with a radio-immunoassay. Statistically significant differences between pretreatment and treatment values were calculated with the paired "t" test. Although treatment values were frequently higher than those before treatment, there were no significant differences between pretreatment and treatment values for glucose and insulin levels with the preparations, with the following exceptions after 6 treatment cycles: a lower fasting glucose level with monophasic desogestrel, a higher 30-minute glucose value with triphasic levonorgestrel, and a higher 180-minute insulin level with monophasic norethisterone. The area under the curve for insulin and glucose was not changed significantly for all prepartions during treatment. Total hemoglobin A and glycosylated proteins were not influenced by any of the preparations with the exception of a significant decrease with monophasic levonorgestrel during treatment. No significant difference was found between the different preparations except that monophasic levonorgestrel was associated with significantly lower hemoglobin Al values compared with those of the other 6 preparations and that monophasic cyproterone acetate had significantly lower hemoglobin Al values than monophasic norethisterone after treatment for 6 months. In sum, the low-dose OCs investigated did not have any adverse effects on glucose metabolism after treatment for 6 months.
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Effect of seven low-dose combined oral contraceptive preparations on carbohydrate metabolism.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Controlled Clinical Trial, Research Support, Non-U.S. Gov't