Linked Life Data

3576907

Source:http://linkedlifedata.com/resource/pubmed/id/3576907

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1987-5-22
pubmed:abstractText
Purulent bronchopneumonia was induced in 12 young calves inoculated endotracheally with a total of 2 to 8 X 10(10) viable Haemophilus somnus organisms. Calves treated before inoculation of bacteria with dexamethasone had more extensive lung changes than nontreated calves. Two of six dexamethasone-pretreated calves died while none of the non-pretreated calves died in the 12-day experimental period. Cranial-ventral gray to red lung consolidations with multifocal abscesses were present in all calves. Histologic examination revealed purulent to fibrinopurulent bronchiolitis accompanied by alveolar filling with fibrin, neutrophils, and macrophages. In addition, peribronchiolar fibrosis and bronchiolitis obliterans were common as were interlobular fibrosis and thrombosis of interlobular and pleural lymphatics. Focal to diffuse ulceration of bronchiolar epithelium was present in five of 12 lungs. Abscessation and severe alveolar filling with fibrin, red blood cells, and streaming inflammatory cells were present in dexamethasone-treated calves. H. somnus was isolated from lungs of all 12 calves. Complement fixation and microagglutination antibody titers to H. somnus antigens increased in most calves following infection with H. somnus. This model of H. somnus pneumonia closely resembles the naturally occurring disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0300-9858
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
129-34
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Experimental Haemophilus somnus pneumonia in calves.
pubmed:publicationType
Journal Article