Linked Life Data

3576071

Source:http://linkedlifedata.com/resource/pubmed/id/3576071

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1987-6-19
pubmed:abstractText
Hepatocyte nodules produced by cyclic feeding of the rat liver carcinogen 2-acetylaminofluorene to male rats have been shown to exhibit specific metabolic characteristics. None of the characteristics of nodular tissue so far investigated has provided any explanation why initiated cells, such as in the "resistant hepatocyte model," were resistant to the mitoinhibitory effects of 2-acetylaminofluorene. In the present study, hepatocyte nodules are produced by cyclic feeding of 0.05% 2-AAF in the diet to male Wistar rats. N-hydroxy-2-acetylaminofluorene sulfotransferase levels were determined in the postmicrosomal supernatant prepared from nodules and from control rat liver. The average sulfotransferase activities were 0.29 and 4.75 nmol p-nitrophenol formed/min X mg protein, respectively. We suggest that the low sulfotransferase activity in preparations from nodular tissue might be an important part of the explanation for the resistance of focal and nodular tissue to the mitoinhibitory effects of 2-acetylaminofluorene.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0192-6233
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
103-5
pubmed:dateRevised
2009-7-1
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Sulfation of N-hydroxy-2-acetylaminofluorene in normal and nodular liver from male Wistar rats.
pubmed:publicationType
Journal Article, Comparative Study