Linked Life Data

3574602

Source:http://linkedlifedata.com/resource/pubmed/id/3574602

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1987-5-26
pubmed:abstractText
Heterozygous Brattleboro (HZ) rats exhibit a partial genetic deficiency in hypothalamic vasopressin (VP) production. The effects of this abnormality of HZ rats on the capacities of VP-neurons and oxytocin (OT)-neurons to respond to an acute salt-load were examined. Acute salt-loading was induced by intravenous infusion of 18% saline in conscious, chronically catheterized animals and the activities of VP-neurons and OT-neurons were interpreted from plasma concentrations of VP-associated neurophysin, [VP-RNP] and OT-associated neurophysin, [OT-RNP] at different time periods throughout the infusion. Plasma sodium concentration ([Na+]), plasma osmolality (Posm) and mean arterial pressure (MAP) were also monitored. Salt-loading produced significant rises in [VP-RNP] and [OT-RNP]. These rises were accompanied by increases in plasma [Na+], Posm and MAP. Releases of OT-RNP were approximately four times greater than those of VP-RNP. The responsiveness of VP-neurons to increases in Posm in the HZ rat was approximately one-half of that observed for the Long-Evans (LE) rat. Furthermore, the responsiveness of OT-neurons in these animals was approximately one-half of that for LE rats and one-third of that for homozygous Brattleboro (DI) rats. The changes in MAP during salt-loading do not appear to be different for HZ and LE rats. Hence, while VP may be involved in the rise in blood pressure during infusion of hypertonic saline, there is not a direct correlation between plasma levels of VP-RNP (and presumably VP) and rises in blood pressure.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0028-3835
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
93-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Reduced responsiveness to acute salt-loading of vasopressin-neurons and oxytocin-neurons in the heterozygous Brattleboro rat.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't