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Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
|
pubmed:dateCreated |
1987-6-10
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pubmed:abstractText |
5-Aroyl-6-substituted-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carbo xylic acids were synthesized and assayed for analgesic and antiinflammatory activity. Several of these compounds, notably the 5-(4-fluoro- and 4-chlorobenzoyl)-6-methyl derivatives 25 and 26 and the 5-(4-methyl-, 4-fluoro-, 4-chloro-, and 4-methoxybenzoyl)-6-chloro congeners 31-34 were of equal or greater potency than indomethacin as antiinflammatory and analgesic agents both in acute and chronic animal models.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
0022-2623
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
30
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
N
|
pubmed:pagination |
820-3
|
pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:3572970-Analgesia,
pubmed-meshheading:3572970-Animals,
pubmed-meshheading:3572970-Carboxylic Acids,
pubmed-meshheading:3572970-Chemical Phenomena,
pubmed-meshheading:3572970-Chemistry,
pubmed-meshheading:3572970-Inflammation,
pubmed-meshheading:3572970-Magnetic Resonance Spectroscopy,
pubmed-meshheading:3572970-Mice,
pubmed-meshheading:3572970-Pyrroles,
pubmed-meshheading:3572970-Rats,
pubmed-meshheading:3572970-Structure-Activity Relationship
|
pubmed:year |
1987
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pubmed:articleTitle |
Synthesis and antiinflammatory and analgesic activity of 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids. The 6-substituted compounds.
|
pubmed:publicationType |
Journal Article,
Comparative Study
|